My caption 😄
CTCF-dependent chromatin insulator as a built-in attenuator of angiogenesis
Abstract
VEGF is a pivotal pro-angiogenic growth factor and its dosage decisively impacts vascularization. We recently identified a CTCF-dependent chromatin insulator that critically restrains the transcriptional induction of VEGF and angiogenesis. We postulate that CTCF may exert enhancer blocking by mediating chromatin looping and/or RNA polymerase pausing at the VEGF locus.
Type
Publication
In Transcription, Transcription.
Date
March, 2012
Links
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