Topic
Sample swaps
How do I verify the samples in my matrix are the samples on the labels?
Swaps and mislabels happen at the bench, at the core and in the metadata spreadsheet. XIST, chrY gene expression and genotype concordance give you an independent identity check that takes minutes and has saved entire studies.
- How to Catch a Sample Swap in Variant Calling
X heterozygosity, chrY coverage and pairwise genotype concordance take minutes to compute and catch mislabels that no alignment or variant-quality QC report will ever flag.