Format
CRAM
Reference-compressed alignments, roughly half the size of BAM; useless without the exact reference FASTA it was written against.
Extensions: .cram, .crai · Coordinates: 1-based-closed · Specification
From CRAM
No conversions from this format yet.
To CRAM
- How to Convert BAM to CRAM (and What Changes Between Builds)
CRAM cuts your disk usage roughly in half and quietly makes the file unreadable without the exact reference FASTA it was built against.