https://divingintogeneticsandgenomics.com/tags/hypergeometric/ Recent content in Hypergeometric on Chatomics Hugo -- gohugo.io en-us © 2018 Ming 'Tommy' Tang Thu, 30 Oct 2014 10:23:00 -0700 https://divingintogeneticsandgenomics.com/archive/test-significance-of-overlapping-genes-from-2-gene-sets/ Thu, 30 Oct 2014 10:23:00 -0700 https://divingintogeneticsandgenomics.com/archive/test-significance-of-overlapping-genes-from-2-gene-sets/ The question is very straightforward: I have three microarray or RNA-seq data sets (control, treatment1, treatment2, each should have several replicates, otherwise you can not get a pvalue for differential expression!) , I then get two sets of differentially up-regulated genes ( treatment1 vs control, treatment2 vs control). There are some overlapping genes which are both up-regulated by treatment1 and treatment2. How significant the overlapping is? The easiest way is to use an online program http://nemates.